SLU-PP-332

Name: SLU-PP-332
Brand: Canada Peptides
Price: 125.0 CAD
Availability: InStock

$125.00

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This batch of SLU-PP-332 Peptide has been third party lab tested and verified for quality.

Contents: SLU-PP-332 (PPARδ/PPARα Modulator)
Form: Powder
Purity: 99.3%

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SLU-PP-332 – Pan-ERR Agonist (Exercise-Mimetic Compound)

SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ)—nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism, and energy expenditure. It has been identified as a potent metabolic modulator capable of mimicking the molecular effects of endurance exercise. SLU-PP-332 is of growing interest in metabolic, mitochondrial, and exercise physiology research for its ability to reprogram energy metabolism in skeletal muscle and adipose tissue.

Overview

SLU-PP-332 acts as a pan-ERR agonist, binding with high affinity to all three ERR isoforms. Activation of these transcription factors induces expression of genes involved in mitochondrial oxidative phosphorylation, fatty acid β-oxidation, and tricarboxylic acid (TCA) cycle function.

In preclinical models, SLU-PP-332 increased mitochondrial density, enhanced endurance performance, improved glucose and lipid metabolism, and reduced body fat independent of food intake. These findings suggest the compound effectively simulates several biochemical adaptations typically associated with aerobic training.

Chemical Makeup

Chemical Name: SLU-PP-332
Molecular Formula: C18H14N2O2
Molecular Weight: 290.32 g/mol
Compound Class: Small-molecule ERR pan-agonist
Mechanism: Direct activation of ERRα/β/γ nuclear receptors
Form: Lyophilized solid
Purity: ≥98% (per COA)
CAS Number: 303760-60-3

Research and Experimental Applications

Mitochondrial Biogenesis and Energy Metabolism

SLU-PP-332 induces mitochondrial biogenic pathways via coactivation of PGC-1α and ERRα, leading to elevated mitochondrial content and oxidative enzyme expression in muscle and liver tissue.

Exercise-Mimetic and Endurance Models

In vivo studies demonstrate enhanced endurance and metabolic efficiency following SLU-PP-332 administration. Treated mice displayed increased aerobic capacity, improved substrate utilization, and elevated fatty acid oxidation markers.

Lipid and Glucose Homeostasis

The compound reduces fat accumulation and improves glucose tolerance by shifting energy metabolism toward oxidative pathways. This makes SLU-PP-332 a valuable tool for research in obesity, insulin resistance, and metabolic syndrome.

Muscle and Mitochondrial Health

By promoting oxidative fiber remodeling and upregulating mitochondrial enzymes, SLU-PP-332 supports research into sarcopenia, mitochondrial dysfunction, and aging-related energy deficits.

Mechanistic Studies

ERR activation by SLU-PP-332 modulates transcription of PGC-1α-dependent genes, including CPT1, MCAD, TFAM, and COX subunits, demonstrating broad mitochondrial and metabolic gene engagement.

SLU-PP-332 is available for research and laboratory purposes only. Not for human consumption.

References

Billon GJ, et al. Synthetic ERRα/β/γ agonist induces an acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(6):756–768. https://pubmed.ncbi.nlm.nih.gov/36988910/
Billon GJ, et al. Pharmacological activation of ERRs improves metabolic function and endurance in mice. J Pharmacol Exp Ther. 2024;388(2):232–243. https://pubmed.ncbi.nlm.nih.gov/37739806/
Pino MF, et al. Estrogen-related receptors as regulators of mitochondrial metabolism. Trends Endocrinol Metab. 2018;29(8):496–509. https://pubmed.ncbi.nlm.nih.gov/29914871/
Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95(6):568–578. https://pubmed.ncbi.nlm.nih.gov/15358669/
Mootha VK, et al. ERRα and PGC-1α coordinate mitochondrial oxidative metabolism. Proc Natl Acad Sci U S A. 2004;101(17):6570–6575. https://pubmed.ncbi.nlm.nih.gov/15087505/
Schreiber SN, et al. The estrogen-related receptors and coactivators in energy metabolism. J Biol Chem. 2004;279(48):49330–49337. https://pubmed.ncbi.nlm.nih.gov/15371420/
Bonnelye E, et al. ERR family in metabolic homeostasis. Mol Cell Endocrinol. 2020;505:110710. https://pubmed.ncbi.nlm.nih.gov/31837419/
Kamei Y, et al. ERRs regulate skeletal muscle oxidative capacity. J Biol Chem. 2003;278(36):33995–34002. https://pubmed.ncbi.nlm.nih.gov/12807910/
Giguère V. ERRs as metabolic regulators and drug targets. Endocr Rev. 2008;29(6):677–696. https://pubmed.ncbi.nlm.nih.gov/18664618/
Tocris Bioscience. SLU-PP-332 product data. https://www.tocris.com/products/slu-pp-332_8112

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